Full 2025 schedule
| Date | Opponent | Result or time | Venue |
|---|
| at Los Angeles Dodgers | L 4-5 | Dodger Stadium |
| at Los Angeles Dodgers | L 5-8 | Dodger Stadium |
| at Los Angeles Dodgers | L 3-7 | Dodger Stadium |
| at Seattle Mariners | W 9-6 | T-Mobile Park |
| at Seattle Mariners | W 4-1 | T-Mobile Park |
| at Seattle Mariners | L 2-3 | T-Mobile Park |
| vs. Chicago White Sox | W 7-4 | Comerica Park |
| vs. Chicago White Sox | W 7-2 | Comerica Park |
| vs. Chicago White Sox | W 4-3 | Comerica Park |
| vs. New York Yankees | W 6-2 | Comerica Park |
| vs. New York Yankees | W 5-0 | Comerica Park |
| vs. New York Yankees | L 3-4 | Comerica Park |
| at Minnesota Twins | W 7-6 | Target Field |
| at Minnesota Twins | W 4-0 | Target Field |
| at Minnesota Twins | L 1-5 | Target Field |
| at Milwaukee Brewers | W 9-1 | American Family Field |
| at Milwaukee Brewers | L 0-5 | American Family Field |
| at Milwaukee Brewers | L 1-5 | American Family Field |
| vs. Kansas City Royals | W 6-1 | Comerica Park |
| vs. Kansas City Royals | W 7-3 | Comerica Park |
| vs. Kansas City Royals | W 3-1 | Comerica Park |
| vs. Kansas City Royals | L 3-4 | Comerica Park |
| vs. San Diego Padres | W 6-4 | Comerica Park |
| vs. San Diego Padres | L 0-2 | Comerica Park |
| vs. San Diego Padres | W 6-0 | Comerica Park |
| vs. Baltimore Orioles | W 4-3 | Comerica Park |
| vs. Baltimore Orioles | W 6-2 | Comerica Park |
| vs. Baltimore Orioles | W 7-0 | Comerica Park |
| at Houston Astros | L 5-8 | Daikin Park |
| at Houston Astros | L 4-6 | Daikin Park |
| at Houston Astros | W 7-4 | Daikin Park |
| at Los Angeles Angels | W 10-4 | Angel Stadium |
| at Los Angeles Angels | W 9-1 | Angel Stadium |
| at Los Angeles Angels | L 2-5 | Angel Stadium |
| at Los Angeles Angels | W 13-1 | Angel Stadium |
| at Colorado Rockies | W 8-6 | Coors Field |
| at Colorado Rockies | W 10-2 | Coors Field |
| at Colorado Rockies | W 11-1 | Coors Field |
| vs. Texas Rangers | W 2-1 | Comerica Park |
| vs. Texas Rangers | L 3-10 | Comerica Park |
| vs. Texas Rangers | L 1-6 | Comerica Park |
| vs. Boston Red Sox | W 14-2 | Comerica Park |
| vs. Boston Red Sox | W 10-9 | Comerica Park |
| vs. Boston Red Sox | W 6-5 | Comerica Park |
| at Toronto Blue Jays | W 5-4 | Rogers Centre |
| at Toronto Blue Jays | L 1-2 | Rogers Centre |
| at Toronto Blue Jays | W 3-2 | Rogers Centre |
| at St. Louis Cardinals | L 4-11 | Busch Stadium |
| at St. Louis Cardinals | W 5-4 | Busch Stadium |
| at St. Louis Cardinals | W 5-1 | Busch Stadium |
| vs. Cleveland Guardians | L 0-7 | Comerica Park |
| vs. Cleveland Guardians | L 1-3 | Comerica Park |
| vs. Cleveland Guardians | L 5-7 | Comerica Park |
| vs. Cleveland Guardians | W 5-0 | Comerica Park |
| vs. San Francisco Giants | W 3-1 | Comerica Park |
| vs. San Francisco Giants | W 3-1 | Comerica Park |
| vs. San Francisco Giants | W 4-3 | Comerica Park |
| at Kansas City Royals | W 7-5 | Kauffman Stadium |
| at Kansas City Royals | L 0-1 | Kauffman Stadium |
| at Kansas City Royals | W 1-0 | Kauffman Stadium |
| at Chicago White Sox | W 13-1 | Rate Field |
| at Chicago White Sox | L 1-8 | Rate Field |
| at Chicago White Sox | W 5-4 | Rate Field |
| at Chicago White Sox | L 2-3 | Rate Field |
| vs. Chicago Cubs | W 3-1 | Comerica Park |
| vs. Chicago Cubs | L 1-6 | Comerica Park |
| vs. Chicago Cubs | W 4-0 | Comerica Park |
| at Baltimore Orioles | W 5-3 | Oriole Park at Camden Yards |
| at Baltimore Orioles | L 1-10 | Oriole Park at Camden Yards |
| at Baltimore Orioles | W 4-1 | Oriole Park at Camden Yards |
| vs. Cincinnati Reds | W 11-5 | Comerica Park |
| vs. Cincinnati Reds | L 1-11 | Comerica Park |
| vs. Cincinnati Reds | L 4-8 | Comerica Park |
| vs. Pittsburgh Pirates | W 7-3 | Comerica Park |
| vs. Pittsburgh Pirates | W 9-2 | Comerica Park |
| vs. Pittsburgh Pirates | L 4-8 | Comerica Park |
| at Tampa Bay Rays | L 8-14 | George M. Steinbrenner Field |
| at Tampa Bay Rays | L 3-8 | George M. Steinbrenner Field |
| at Tampa Bay Rays | W 9-3 | George M. Steinbrenner Field |
| vs. Athletics | W 11-4 | Comerica Park |
| vs. Athletics | L 0-3 | Comerica Park |
| vs. Athletics | W 8-0 | Comerica Park |
| vs. Minnesota Twins | L 1-4 | Comerica Park |
| vs. Minnesota Twins | W 10-5 | Comerica Park |
| vs. Minnesota Twins | W 3-0 | Comerica Park |
| at Washington Nationals | L 4-9 | Nationals Park |
| at Washington Nationals | W 11-2 | Nationals Park |
| at Washington Nationals | L 7-11 | Nationals Park |
| at Cleveland Guardians | W 2-1 | Progressive Field |
| at Cleveland Guardians | W 1-0 | Progressive Field |
| at Cleveland Guardians | W 7-2 | Progressive Field |
| vs. Tampa Bay Rays | W 5-1 | Comerica Park |
| vs. Tampa Bay Rays | W 4-2 | Comerica Park |
| vs. Tampa Bay Rays | L 3-7 | Comerica Park |
| vs. Seattle Mariners | L 3-12 | Comerica Park |
| vs. Seattle Mariners | L 7-15 | Comerica Park |
| vs. Seattle Mariners | L 4-8 | Comerica Park |
| at Texas Rangers | L 0-2 | Globe Life Field |
| at Texas Rangers | L 1-4 | Globe Life Field |
| at Texas Rangers | W 2-1 | Globe Life Field |
| at Pittsburgh Pirates | L 0-3 | PNC Park |
| at Pittsburgh Pirates | L 5-8 | PNC Park |
| at Pittsburgh Pirates | L 1-6 | PNC Park |
| vs. Toronto Blue Jays | L 4-11 | Comerica Park |
| vs. Toronto Blue Jays | L 2-6 | Comerica Park |
| vs. Toronto Blue Jays | L 1-6 | Comerica Park |
| vs. Toronto Blue Jays | W 10-4 | Comerica Park |
| vs. Arizona Diamondbacks | W 5-1 | Comerica Park |
| vs. Arizona Diamondbacks | W 12-2 | Comerica Park |
| vs. Arizona Diamondbacks | W 7-2 | Comerica Park |
| at Philadelphia Phillies | L 4-5 | Citizens Bank Park |
| at Philadelphia Phillies | W 7-5 | Citizens Bank Park |
| at Philadelphia Phillies | L 0-2 | Citizens Bank Park |
| vs. Minnesota Twins | W 6-3 | Comerica Park |
| vs. Minnesota Twins | L 3-6 | Comerica Park |
| vs. Minnesota Twins | L 4-9 | Comerica Park |
| vs. Los Angeles Angels | W 6-5 | Comerica Park |
| vs. Los Angeles Angels | L 4-7 | Comerica Park |
| vs. Los Angeles Angels | W 9-5 | Comerica Park |
| at Chicago White Sox | W 2-1 | Rate Field |
| at Chicago White Sox | L 6-9 | Rate Field |
| at Chicago White Sox | W 1-0 | Rate Field |
| at Minnesota Twins | W 4-3 | Target Field |
| at Minnesota Twins | W 7-0 | Target Field |
| at Minnesota Twins | W 8-5 | Target Field |
| at Minnesota Twins | L 1-8 | Target Field |
| vs. Houston Astros | W 10-0 | Comerica Park |
| vs. Houston Astros | W 1-0 | Comerica Park |
| vs. Houston Astros | W 7-2 | Comerica Park |
| vs. Kansas City Royals | W 7-5 | Comerica Park |
| vs. Kansas City Royals | W 4-2 | Comerica Park |
| vs. Kansas City Royals | L 8-10 | Comerica Park |
| at Athletics | L 3-8 | Sutter Health Park |
| at Athletics | L 6-7 | Sutter Health Park |
| at Athletics | L 0-7 | Sutter Health Park |
| at Kansas City Royals | W 5-3 | Kauffman Stadium |
| at Kansas City Royals | L 1-3 | Kauffman Stadium |
| at Kansas City Royals | W 5-0 | Kauffman Stadium |
| vs. New York Mets | L 8-10 | Comerica Park |
| vs. New York Mets | L 5-12 | Comerica Park |
| vs. New York Mets | W 6-2 | Comerica Park |
| vs. Chicago White Sox | L 5-7 | Comerica Park |
| vs. Chicago White Sox | W 6-0 | Comerica Park |
| vs. Chicago White Sox | L 4-6 | Comerica Park |
| at New York Yankees | W 12-2 | Yankee Stadium |
| at New York Yankees | W 11-1 | Yankee Stadium |
| at New York Yankees | L 3-9 | Yankee Stadium |
| at Miami Marlins | L 2-8 | loanDepot park |
| at Miami Marlins | L 4-6 | loanDepot park |
| at Miami Marlins | W 2-0 | loanDepot park |
| vs. Cleveland Guardians | L 5-7 | Comerica Park |
| vs. Cleveland Guardians | L 0-4 | Comerica Park |
| vs. Cleveland Guardians | L 1-3 | Comerica Park |
| vs. Atlanta Braves | L 1-10 | Comerica Park |
| vs. Atlanta Braves | L 5-6 | Comerica Park |
| vs. Atlanta Braves | L 2-6 | Comerica Park |
| at Cleveland Guardians | L 2-5 | Progressive Field |
| at Cleveland Guardians | L 1-5 | Progressive Field |
| at Cleveland Guardians | W 4-2 | Progressive Field |
| at Boston Red Sox | L 3-4 | Fenway Park |
| at Boston Red Sox | W 2-1 | Fenway Park |
| at Boston Red Sox | L 3-4 | Fenway Park |